In the round of 16, the eight group winners are joined by the eight winners of the knockout round play-offs.
The round of 16 pairings are determined by means of a draw, in accordance with the following principles:
The UEFA Europa League group winners must be drawn against the eight winners of the knockout round play-offs.
Clubs from the same association cannot be drawn against each other.
The UEFA Europa League group winners play the return leg at home.
The eight winners of the round of 16 qualify for the quarter-finals.
The round of 16 matches are played under the knockout system, in two legs, home and away. The team that scores the greater aggregate of goals in the two matches qualifies for the next stage. Otherwise,applies.