After the match sheets have been exchanged, no changes are allowed. Before the match has kicked off, the following exceptions apply:
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Any outfield player indicated as one of the starting five on the match sheet who cannot start the match due to physical incapacity may be replaced by one of the substitutes listed on the match sheet. The replaced player is taken off the match sheet and the team's quota of substitute players is reduced accordingly for the match in question.
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Any substitute player listed on the match sheet who cannot be fielded due to physical incapacity may not be replaced, which means that the quota of substitute players is reduced accordingly for the match in question.
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Any goalkeeper listed on the match sheet who cannot be fielded due to physical incapacity may be replaced by another goalkeeper.
The association concerned must submit to the UEFA match delegate a printed copy of the match sheet duly completed in relation to the specific change. In addition, the association concerned must submit the medical replacement form to the UEFA administration within 48 hours of the end of the match, along with any necessary medical evidence. If it fails to do so or if UEFA finds any of the information provided by the association concerned to be inaccurate, the matter may be referred to the UEFA disciplinary bodies. A replaced player who is taken off the match sheet may take no further part in the match nor sit on the team bench.
The maximum number of substitutes permitted per team is seven (final tournament: nine). The number of substitutions permitted during a match is unlimited. No substitutions are allowed during time-outs.
Any player selected on the match sheet in line with Article 47 or replaced in line with Article 48 may be selected to undergo a doping control after the match in accordance with Annex B of the UEFA Anti-Doping Regulations and must remain available in the hall for 30 minutes after the end of the match. If a doping control officer is present at the match and a player selected on the match sheet is injured or falls ill and requires treatment in hospital, the doping control officer assesses the severity of the injury or illness and decides whether the player can leave the hall to go to hospital immediately or whether they must undergo any potential doping control first.