After the match sheets have been exchanged, no changes are allowed. Before the match has kicked off, the following exceptions are possible:
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Any of the outfield players indicated on the match sheet as forming the starting 11 who cannot start the match due to physical incapacity may be replaced by one of the substitutes indicated on the match sheet. The replaced player is taken off the match sheet and the number of substitutes is reduced accordingly for the match in question. During the match, five players may still be substituted.
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Substitute outfield players indicated on the match sheet who cannot be fielded due to physical incapacity may not be replaced, which means that the number of substitutes is reduced accordingly for the match in question.
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A starting goalkeeper indicated on the match sheet who cannot be fielded due to physical incapacity may be replaced by one of the substitutes indicated on the match sheet. The replaced goalkeeper may still be used as a substitute goalkeeper or, if this is not possible, be replaced by a goalkeeper not previously registered on the list of 20 players in accordance with Article 39 (in which case the player list in question is automatically amended).
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A substitute goalkeeper who cannot be fielded due to physical incapacity may be replaced by a goalkeeper not previously registered on the list of 20 players in accordance with with Article 39 (in which case the player list in question is automatically amended).
The association concerned must submit to the UEFA match delegate a printed copy of the match sheet indicating the change and signed by the team doctor. If it fails to do so, any change made to the starting 11 indicated on the match sheet after the match sheets have been exchanged is considered a substitution, and the number of substitutions available to the team during the match is reduced accordingly. In addition, the association concerned must submit the medical replacement form to the UEFA administration within 48 hours of the end of the match, along with any necessary medical evidence. If it fails to do so or if UEFA finds any of the information provided by the association concerned to be inaccurate, the matter may be referred to the UEFA disciplinary bodies. A replaced player who is taken off the match sheet may take no further part in the match nor sit on the team bench or any additional seats reserved for team officials selected on the match sheet.
Up to five of the substitutes listed on each team’s match sheet may take part in the match. A player who has been substituted may take no further part in the match. Each team may use a maximum of three stoppages in play to make substitutions. Substitutions made before the start of the match and during half-time do not reduce the number of stoppages in play that can be used.
Any player selected on the match sheet in line with Article 59 or replaced in line with Article 60 may be selected to undergo a doping control after the match in accordance with Annex B of the UEFA Anti-Doping Regulations and must remain available in the stadium for 30 minutes after the end of the match. If a doping control officer is present at the match and a player selected on the match sheet is injured or falls ill and requires treatment in hospital, the doping control officer assesses the severity of the injury or illness and decides whether the player can leave the stadium to go to hospital immediately or whether they must undergo any potential doping control first.