After the match sheets have been exchanged, no changes are allowed. Before the match has kicked off, the following exceptions are possible:
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Any of the players indicated on the match sheet as forming the starting 11 who cannot start the match due to physical incapacity may be replaced by one of the substitutes listed on the match sheet.
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If none of the goalkeepers listed on the match sheet can be fielded due to physical incapacity, they may be replaced by registered goalkeepers included on the list of 40 players.
The club concerned must provide the UEFA administration with the necessary medical certificates. Any change made to the players indicated on the match sheet as forming the starting 11 after the match sheets have been exchanged without providing due medical evidence is considered as a substitution, and the number of substitutions available to the team during the match is reduced accordingly. The replaced player may take no further part in the match.
Up to five of the substitutes listed on each team’s match sheet may take part in the match. A player who has been substituted may take no further part in the match. Each team may use a maximum of three stoppages in play to make substitutions. Substitutions made before the start of the match and during half-time do not reduce the number of stoppages in play that can be used.
Any player selected on the match sheet in line with Article 46 or replaced in line with Article 47 may be selected to undergo a doping control after the match in accordance with Annex B of the UEFA Anti-Doping Regulations and must remain available in the stadium for 30 minutes after the end of the match. If a doping control officer is present at the match and a player selected on the match sheet is injured or falls ill and requires treatment in hospital, the doping control officer assesses the severity of the injury or illness and decides whether the player can leave the stadium to go to hospital immediately or whether they must undergo any potential doping control first.